Z-arylamino-x-halogenoqtjinolines



Patented June 7, 1949 UNITED STATES PATENT OFFICE Francis Henry Swinden Curd, Clifl-ord Gordon Raison, and Francis Leslie Rose, Blackley, Manchester, England, assignors to Imperial Chemical Industries Limite Britain d, a corporation of Great No Drawing. Application July 31, 1945, Serial N 0. 608,087. In Great Britain August 31, 1944 1 Claim.

This invention relates to the manufacture of new heterocyclic compounds. More particularly it relates to the manufacture of new quinoline derivatives which are useful as intermediates in the manufacture of chemotherapeutic agents and especially of the compounds of copending application of Curd, Landquist, Raison and Rose, serial No. 608,088, of even filing date herewith.

According to the invention we make new 4-halogenoquinolines which bear in the Z-position an arylamino group which may be unsubstituted or may bear one or more non-acidic substituents such, for example, as halogen atoms, nitro groups, hydrocarbon radicals (which themselves may bear simple substituents and which may be attached to the arylamino group directly or through an oxygen, nitrogen or sulphur atom or through a sulphonyl or carbonyl group), cyano groups or esterified carboxyl groups, and which optionally bear in the other nuclear positions one or more non-acidic substituents, for example, alkyl, alkoxy, halogeno or nitro groups, or fused-on carbocyclic rings (as, for example, in 7:8-benzoquinoline), by a process comprising the interaction of an appropriate arylamine with a 2:4-dihalogeno-quinoline. The dihalogenoquinoline is preferably used in substantially the stoichiometric proportion; an excess may be used if desired, but with no advantage. A large excess of the arylamine should be avoided as it may lead to the formation of the di-arylamino compound.

The reaction is conveniently brought about by heating the reagents together, optionally in presence of a solvent or diluent. If desired, a catalyst, such as a small proportion of the arylamine hydrochloride, may be used.

As already indicated, the arylamines to be used in this process may be substituted or unsubstituted, but they must be devoid of acidic substituents such as carboxylic or sulphonic acid groups or phenolic groups. As examples of suitable amines there may be mentioned aniline, o, mand p-chloroanilines, oand p-methoxy-" anilines, mand p-toluidines, o, and p-bromoanilines, p-methylmercaptoaniline, 2:4-, 3:4- and 2 5-dichloroanilines, 3 :4-dimethylaniline, 2- methyl 4 chloroaniline, 3 chloro 4 methylaniline, p-dimethylaminoaniline, p-nitroaniline,

p-cyanoaniline, p-carbomethoxyaniline, p-ethoxyaniline, p-n-butylaniline, p-phenylaniline, aand ,e-naphthylamines, 4-chloro-a-naphthylamine, G-bromo-p-naphthylamine and 6-methoxy-p-naphthylamine.

The following examples, in which the parts are by weight, illustrate but do not limit the invention.

Example 1 A mixture of 19.8 parts of 2:4-dichloroquinoline, 12.75 parts of p-chloroaniline and 40 parts of acetic acid is heated and stirred at -100 C. for 2 hours. The mixture is cooled and diluted with a large volume of water. A precipitate is formed. This is filtered 01f and boiled with methanol. Ammonia is then added until the mixture is alkaline. A large volume of water is added and the mixture is cooled whereupon a precipitate is formed. This is filtered 011 and dried. It is 2-p-choloranilino-4-chloroquinoline. By crystallisation from methanol it is obtained as pale yellow needles, M. P '134-136 C.

Example 2 A mixture of 19.8 parts of 2:4-dichloroquinoline, 12.75 parts of p-chloroaniline and 40 parts of chlorobenzene is stirred and heated at C. for 2 hours. The reaction mixture is cooled and 60 parts of benzene are added. The solid which separates is filtered off and dried. It is then boiled with 100 parts of methanol. The mixture is basified by addition of ammonia, and then diluted with a large volume of water. On cooling, a solid separates out. It is filtered off and dried and crystallised from methanol. There is thus obtained 2-p-chloroanilino-4-chloroquinoline in the form of pale yellow needles, M. P. -136 C.

Example 3 A mixture of 14.85 parts of 2:4-dichloroquinoline, 7 parts of aniline and 30 parts of acetic acid is heated and stirred at 95-100 C. for 1 hour. The reaction is now complete and the product is present as its hydrochloride. 15 parts of fused sodium acetate are added and after heating for a further hour, the mixture is cooled and diluted with a large volume of water. A precipitate is formed. This is Washed with water by decantation and 35 parts of methanol are added. The undissolved material is filtered ofi, washed with methanol, dried and then crystallised from ethanol. There is thus obtained 2-anilino-4-chloroquinoline in the form of pale yellow prisms, M. P. 162-163 0.

Example 4 A mixture of 39.6 parts of 2:4-dichloroquinoline, 24.6 parts of p-anisidine and 80 parts of acetic acid is heated and stirred at 95100 C. for-2 hours. The reaction mixture is then cooled Example '5 A mixture of 39.6 parts of 2:'4'-.dicliloro-quinoline, 21.4 parts of p-toluidine and 80' parts of acetic acid is heated and stirred at 95-100 C. for 2 hours. The reaction mixture is cooled and diluted with a large volumeof water; Apreclpitate is formed which is washed with waterby decantation and then boiled with 150 .partsoimethanol. Ammonia is added until the mixture is alkaline and then a large volume of water is.

added and the mixture is cooled. The solid which separates out is filtered ofi, dried and crystallised from methanol. There is thus obtained 2-ptoluidino-4-chloroquinoline in the form" o'f' pale yellow prisms, M. P. 115.5-'116.5 C.

Example '6 -A=mixture of 39.6 parts of 2:4-dichlo1'oquinoline',

2 8fi-parts-of fi-naphthylamine and 80 parts-t acetieacitl is heated and stirred at 95-100'C;. forZ-hours. The reaction mixture is cooled and diluted-with a large volume of water. A precipitate' is formed which is washed with water by decantation and then boiled with 150 parts-of methanol. Ammonia is'added until the mixtureis-alkaline-and then a large volume of water. is

added and the mixture is-cooled. A precipitate is formed. The aqueous liquid is decanted off and the sticky precipitate is digested with aqueous.methan'ol (90 parts methanol: parts'water) until it'is solid; It is then filtered oil, washed with. aqueous methanol and'dried'. By crystallisation from aqueousmethanol,Z-B-naphthylami no-4-chloroquinoline' is obtained, M. P; 108"- 110? Cl Example? A mixture of 24.8" parts of 2:4-dichloro-7z8- benzquinoline (M.:P. 134 135 C., made byheat ingmhosphoms oxychloride with 2:4-dihydroxy- 1 '7 zfi benzquinoline, itself obtained from the .reaction of e-naphthylamine with diethyl =malonate).-, 12.7 parts of p-chloroaniline, 0.1 part of p-chloroaniline hydrochloride and 30"parts of ,B-ethoxyethanol isihea'ted and stirred at 160 C. for 3 hours; The initially clear solution soon begins tozdeposit;greenish-yellow crystals. Thermixture isscooled and'ia large volumeof water is added. Thensolid material is filteredofi and dried. It iszth'en boiled'with350 partsof ethanol. Ammonia is added until the mixture .is alkaline andsthe clear solution-is-cooled:and diluted with an equal amount: of: water. The sticky precipitate .so ,pr0- ducedisolidifies on standing and isthenfiltered oif-iand dried. By crystallisation .from. benzeneand -.then from butanol, 2-p-chloroanilino- 4- ohloroJl 8-benzquinoline is obtained vas .masses of bufE-colouredneedles, M. P. 160-1'62 C.

Example 8 A mixture of 33 partsof2z4-dichloroquinoline. 37 ipartsof.- fi-bromo-flmaphthylamine and 75 parts :tofr acetic acid is 9B -1'00-C.tor 1 hour.

heated. and stirred at The reaction mixture-isandrfiltered and thewgreenish-yellow orys cold- .dioxane for. 1 V

tals so obtained are well washed with acetic acid. They are then boiled with 150 parts of methanol and ammonia is added until the mixture is alkaline. After cooling, the mixture is filtered. The residue is washed with methanol and then with water, dried and* crystallised first from aqueous butanol'and then'from n-propanol. There is thus obtained 2- (6'-bromo-;3-naphthylamino) -4-chl0- roquinoline, M. P. 152-154 C.

Example 9 A mi'xtureof 1918 parts of 2 l-dichloroquinoline, 4318 parts of p-nitroaniline and 40 parts of acetic acidis heatedland stirred at 95-100 C. for 2 hours. The reaction mixture is cooled, diluted with water until no more precipitate is formed andfllteredl The: residue is boiled with 200 parts of methanol and ammonia is added until the mixture .is alkaline. A large volume of water is then added and the mixture is cooled. The base whiohlis precipitated isfiltered oil and dried. It is- -thenwrystallised, first from fl-ethoxyethanol and thenfrom dioxane. There is'thus obtained 2-p-nitroanilino- 4-chloroquinoline in the form of golden-.yellowprismsof- M. P. 263 -265 C.

Example 1 0 actionmixtureis.cooled; diluted with water until nosmore, precipitateeisiormed and filtered. The residue is-boiled' with .100 parts of methanol and ammonia is.added.until themixture is alkaline. A large volume of water. isthen added and the mix- I ture .i's.cooled. The base which is precipitated is filtered oil'T-and-dried. Itisboiled with 150 parts of ethanol.and=thehotsolution is filtered and cooled. Whencold,.the crystals whichhave separated out arer'filteredoff andthen stirred with parts of hours. At the end of this time, the -undissolved crystals (which consist of 2 moip-chloroanilino) -3-methylquin0line) are filtered'ofisanddiscarded and the dioxane'solutionis diluted withwaterwhereupon crystals of 2- -p-chloroanilino-3-methyl-4-chloroquinoline separate-out. Afterrecrystallisation from ethanol, it has M. P. 120-121 C.

Example 11- *A mixture of 285 parts of 2 :4dichlcro-3-ethylqui'noli'ne (-B: P. l82 -184'C./21 mm.; made by the action of phosphorus oxychloride on 2:4-dihydroxy 3-ethylquinoline,(itself made by heating aniline -'With' .di'ethyl ethylmalonate), 16.1 parts of p-chlbroaniline and 63'parts of acetic acid is heat'ed -aud stlrred at -400" C. for 2 hours. Thezreactionxmixture. is cooled, diluted'with water untilfzno more precipitate is formed and filtered. Theimesiduesis boiled with' 150 parts of methanol and'iammonia :is'zadde'd until the mixture is alkaline: -A-:large volumaofwateris added and the mixtureisco'oled; The :base which' is precipitated is filtered ioff and dried. It is boiled with partsflof-ethanol andthelhotrsolution is filtered and cooled; -When cold, the crystals which. have separated--out-.are filtered ofi and then stirred with-50.parts of cold dioxane-for.2 hours. At the endlofthis time, .the .undi'ssolved'crystals (which consist of 2 :4-di- (p-chlbro'anilino) -3-.ethylquinoline) are-filtered of! and discardedand-the-di- 6 We claim: 2-p-chloroanlllno-4-chloro-quino1ine.

FRANCIS HENRY SWINDEN CURD. CLIFFORD GORDON RAISON. 5 FRANCIS LESLIE ROSE.

REFERENCES CITED The following references are of record in the 10 file of this patent:

Ephriam, Berichte, 26, 2227-2230 (1893). Niementowski, Berichte, 40, 4285-4294 (1907). 

